Design of an Integrated Quality-Adaptive Multi-Scale Causal Ensemble Framework for Explainable and Risk-Calibrated Screening of Oral Potentially Malignant Disorders
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更新:2026-11-10 16:36:46 浏览:7次
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摘要
There's an urgent need for intelligent screening of oral potentially malignant disorders (OPMDs) so that there can be better early referral to specialists and fewer diagnostic delays. Most current machine learning models have some limitations due to variable lighting conditions; poor or weak localization of lesions; use of a fixed scale representation; the use of constant weighting factors when combining multiple predictors; reliance on shortcuts in explaining how they make their predictions; and poorly calibrated decision-making across centers. In this paper, we propose the Q-MorphoFuse five stage analytic methodology. Q-LESRNet will perform quality conditioned restoration, evidence-based segmentation, and boundary uncertainty estimation. The MorphoSpectral Pyramid Tokenizer will extract features at each level of granularity (spatial, morphology, spectral frequency) which preserves both local subtle textures as well as global architectural characteristics around lesions. CRED Fuse will then combine these feature vectors using the results of three different metrics - causal reliability, epistemic uncertainty, and expert disagreement to produce patient specific ensemble weights. Finally, CoStaX-OPMD will validate model performance against gold standard pathology sensitive and nuisance invariant counterfactual testing thus allowing for identification of potential spurious attentions. Lastly, ConformaRisk-Triage will provide conformal prediction intervals as well as calibrated malignancy risks, and whether it is safe to abstain from further testing or to refer immediately for the process. Overall, our proposed method should lead to improved sensitivity, calibration, explainability, device portability/robustness, and safety in identifying high risk OPMD patients while also decreasing the number of false negatives and unnecessary referrals in resource challenged clinical environments.
关键词
Oral Potentially Malignant Disorders, Intraoral Image Analysis, Multi-Scale Deep Learning, Causal Ensemble Fusion, Conformal Risk Prediction, Scenarios
稿件作者
KIRAN KUMAR CHANUMOLU
K L University
MUNI NAGAMANI G
K L U niverity
GRANDHI APPALARAJU
ADITYA UNIVERSITY
KISHORE KUMAR MAHESWARA
LAKIREDDY BALI REDDY COLLEGE OF ENGINEERING
CH ASHOK KUMAR
VIKAS GROUP OF INSTITUTIONS
MUNI HEMALATHA G
Siddharth Institute of Engineering & Technology
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